CD79a Mouse, PE, Clone: HM47, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-0792-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15546826

Quantity Price
1 £ 78.88 / 25 tests
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Applications Flow Cytometry (Intracellular Staining)
Clone HM47
Host Species Mouse
Isotype IgG1
Quantity 25 tests
Species Reactivity Baboon, Canine, Chicken, Chimpanzee, Cow, Guinea Pig, Horse, Human, Mouse, Non-human primate, Pig, Rat, Rhesus Ma
Antigen CD79a
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Conjugate PE
Gene Alias Ig-alpha, mb-1
Primary or Secondary Primary
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Format Conjugated
Concentration 5μL (0.06μg)

The monoclonal antibody HM47 recognizes the cytoplasmic domain of CD79a, also known as mb-1. CD79a is a 47kDa membrane glycoprotein that associates with CD79b to form the heterodimeric B cell receptor (BCR). This receptor is responsible for B cell signaling, resulting in activation, apoptosis or anergy. Expression of CD79a is found throughout development from the earliest pre-B cell to plasma cells. CD79 is expressed on B cell neoplasms and some non-B cell malignancies such as AML. Unlike other antibodies that can be masked in B cell neoplastic cells, HM47 is a reliable antibody for recognizing CD79a and, as such, is a good marker for B cells. Because several variants of CD79a exist, the exact location of the epitope may differ slightly. Nevertheless, in humans thie epitope is typically amino acids 208-222.

The HM47 antibody reacts to human, mouse, rat, dog, primates (rhesus, chimpanzee, macaque and baboon) pig, guinea rabbit, pig, horse, cow and chicken.