CD79 Mouse anti-Mouse, Clone: 24C2.5, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-0791-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15227077

Quantity Price
1 £ 72.77 / 100µg
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Quantity 100μg
Format Purified
Primary or Secondary Primary
Applications Immunohistochemistry
Applications Western Blotting
Species Reactivity Mouse
Monoclonal or Polyclonal Monoclonal
Antigen CD79
Concentration 0.5mg/mL
Storage Requirements Store at 2-8°C.
Host Species Mouse
Conjugate Unlabeled
Isotype IgG1
Regulatory Status RUO
Clone 24C2.5
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Ig-alpha, mb-1, Ly-54

This 24C2.5 monoclonal antibody reacts with the intracellular tail of mouse CD79a (also known as Ig alpha or mb-1), a signaling component of the B cell receptor (BCR). CD79a heterodimerizes with CD79b (Ig beta, B29), and together with surface Ig, make up the BCR. Both CD79 subunits consist of a single extracellular Ig domain, a transmembrane domain, and an intracellular signaling domain. CD79a is expressed almost exclusively on B cells, as well as in most B lineage acute lymphoblastic leukemias. The cytoplasmic domain of CD79a contains immunoreceptor tyrosine-based activation motifs (ITAMs), which constitute the signal transducing portions of the BCR. Tyrosine phosphorylation of these ITAMs by Syk and Lyn initiates numerous signaling cascades, resulting in B cell activation, proliferation, and differentiation.