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  6. CD71 Mouse anti-Human, APC, Clone: M-A712, BD

CD71 Mouse anti-Human, APC, Clone: M-A712, BD

Product Code. 15851489
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100 Tests
25 Tests
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15851489 25 Tests Each
15816628 100 Tests Each
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Product Code. 15851489 Supplier BD Biosciences Supplier No. 561940

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Description

Mouse Monoclonal Antibody

The M-A712 monoclonal antibody specifically binds to CD71 which is also known as the transferrin receptor (TFR). This type II transmembrane glycoprotein is expressed on cells as a disulfide-linked homodimer comprised of 95 kDa monomers. CD71 is expressed on activated lymphocytes, monocytes, macrophages, erythroid progenitors, brain endothelium, and most proliferating cells. CD71 is not expressed on resting lymphocytes and is upregulated during lymphocyte responses to antigens or mitogens. Through an endocytic pathway, the transferrin receptor mediates cellular iron uptake by binding and internalizing iron that is bound to transferrin. After releasing iron within the low pH endosomal environment, transferrin and its receptor can be recycled to the cell surface.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD71
Applications Flow Cytometry
Classification Monoclonal
Clone M-A712
Conjugate APC
Description TFR; TFRC; Trfr; TfR1; Transferrin receptor protein 1
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Mouse
Immunogen T-CLL and Jurkat Cells
Purification Method Affinity Purified
Quantity 25 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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