Invitrogen™ CD7 Monoclonal Antibody (eBio124-1D1 (124-1D1)), Brilliant Violet™ 650, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen™ 416-0079-42

Product Code. 30019861

Description

CD7 Monoclonal antibody specifically detects CD7 in Human samples. It is validated for Flow Cytometry

CD7, also known as gp40 or Leu9, is a 40 kDa receptor and member of the immunoglobulin gene superfamily. It features an N-terminal region (amino acids 1-107) that is highly homologous to Ig kappa light chains, while its carboxyl-terminal region is proline-rich, forming a stalk from which the Ig domain projects. CD7 is prominently expressed on the majority of immature and mature T lymphocytes, as well as T cell leukemias. It is also found on natural killer cells, a small subpopulation of normal B cells, and malignant B cells. CD7 plays a crucial role in modulating immune cell activity. Cross-linking of surface CD7 enhances T cell and NK cell functions, as evidenced by increased calcium flux, expression of adhesion molecules, cytokine secretion, and proliferation. CD7 directly associates with phosphoinositol 3-kinase, and its ligation induces the production of D-3 phosphoinositides and tyrosine phosphorylation. The expression of CD7 is an important marker in leukemia diagnostics, highlighting its significance in both normal immune function and disease states.

Specifications

• Antigen: CD7
• Classification: Monoclonal
• Concentration: 5 μL/Test
• Formulation: PBS with BSA and 0.09% sodium azide; pH 7.2
• Gene Accession No.: P09564
• Gene Symbols: CD7
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 924
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Flow Cytometry
• Clone: eBio124-1D1 (124-1D1)
• Conjugate: Brilliant Violet 650
• Gene: CD7
• Gene Alias: Cd7; CD7 antigen; CD7 antigen (p41); Cd7 molecule; GP40; LEU-9; p41 protein; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41
• Host Species: Mouse
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ