Invitrogen™ CD7 Monoclonal Antibody (D5), Invitrogen™

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
17989382	Invitrogen™ MA551162	20 μL
17978602	Invitrogen™ MA551161	200 μL

Description

CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily. CD7 contains N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxy-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. Further, CD7 is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. Expression of CD7 is an important marker used in leukemia diagnostics.

Specifications

• Antigen: CD7
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
• Gene Alias: Cd7; CD7 antigen; CD7 antigen (p41); Cd7 molecule; GP40; LEU-9; p41 protein; T-cell antigen CD7; T-cell leukemia antigen; T-cell surface antigen Leu-9; Tp40; TP41
• Gene Symbols: CD7
• Isotype: IgG1 κ
• Purification Method: Protein A/G
• Gene: CD7

• Clone: D5
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human
• Gene Accession No.: P09564
• Gene ID (Entrez): 924
• Immunogen: Recombinant Eukaryotic Human CD7 protein, Ala26-Pro180 (Accession #P09564).
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.