Invitrogen™ CD68 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA589134

Product Code. 16597141

Description

Positive Samples: Mouse fat, Mouse skin, Rat skin; Cellular Location: Cell membrane, Endosome membrane, Lysosome membrane, Single-pass type I membrane protein, Single-pass type I membrane protein Immunogen sequence: NDCPHKKSAT LLPSFTVTPT VTESTGTTSH RTTKSHKTTT HRTTTTGTTS HGPTTATHNP TTTSHGNVTV HPTSNSTATS QGPSTATHSP ATTSHGNATV HPTSNSTATS PGFTSSAHPE PPPPSPSPSP TSKETIGDYT WTNGSQPCVH LQAQIQIRVM YTTQGGGEAW GISVLNPNKT KVQGSCEGAH PHLLLSFPYG HLSFGFMQDL QQKVVYLSYM AVEYNVSFPH AAQWTFSAQN ASLRDLQAPL GQSFSCSNSS IILSPAVHLD LLSLRLQAAQ LPHTGVFGQS FSCPSDRS.

CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysomsomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes. Also, CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukemia studies.

Specifications

• Antigen: CD68
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cd68
• Gene Alias: CD68; CD68 antigen; CD68 molecule; GP110; Lamp4; macrophage antigen CD68; macrosialin; Scard1; scavenger receptor class D, member 1; similar to CD68 antigen
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 968
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.57 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: P34810
• Gene Symbols: Cd68
• Immunogen: Synthetic peptide.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG