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CD63 Rat anti-Mouse, APC, Clone: NVG-2, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-0631-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15597956

  • £177.00 / 100µg

In stock, ready to ship: 2

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Description

Description

A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered. CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. CD63 is also present in the plasma membrane, usually following cell activation. Hence, CD63 has become a widely used basophil activation marker. In mast cells, however, CD63 exposition does not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas. CD63 is expressed on activated platelets, and is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. CD63 is also present in monocytes and macrophages and is weakly expressed on granulocytes, B, and T cells. CD63 is identical to the melanoma-associated antigen which is ME491 and to the platelet antigen PTLGP40. Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.
Specifications

Specifications

CD63
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P41731
LAMP-3, ME491, MLA1, OMA81H, TSPAN30
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
NVG-2
APC
Cd63
Liquid
Cd63
IgG2a, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
12512
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