CD59 (Protectin) Mouse anti-Human, FITC, Clone: OV9A2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 11-0596-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15556426

Quantity Price
1 £ 121.67 / 100 tests
EU Stock 1
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test
Applications Flow Cytometry
Gene Alias MIRL
Isotype IgG1
Primary or Secondary Primary
Quantity 100 tests
Clone OV9A2
Antigen CD59 (Protectin)
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Format Conjugated
Species Reactivity Human
Conjugate FITC
Host Species Mouse
Monoclonal or Polyclonal Monoclonal
Regulatory Status RUO

This OV9A2 monoclonal antibody reacts with human CD59, which is also known as Protectin. This GPI-linked membrane glycoprotein shares structural homology with the murine Ly-6 superfamily. CD59 is expressed on all human lymphocytes, monocytes, granulocytes, and erythrocytes. This protein is also expressed on non-hematopoietic cells, including endothelial cells and neurons. By binding the complement components C8 and C9, CD59 inhibits assembly of the membrane attack complex and cytolytic activity by complement. CD59 interacts with CD2 to modulate T cell adhesion, and also plays a role in T cell activation. Finally, altered expression of CD55 and CD59 on human peripheral blood cells has been observed in patients with systemic lupus erythematosus (SLE).

Crossblocking studies indicate that the OV9A2 monoclonal antibody binds the same epitope as MEM-43.