CD54 (ICAM-1) Rat anti-Mouse, Clone: KAT-1, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-0542-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15278477

Quantity Price
1 £ 182.82 / 500µg
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Concentration 1mg/mL
Isotype IgG2a
Primary or Secondary Primary
Conjugate Unlabeled
Species Reactivity Mouse
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Formulation aqueous buffer, no sodium azide
Quantity 500μg
Storage Requirements Store at 2-8°C.
Regulatory Status RUO
Gene Alias Intercellular adhesion molecule-1
Host Species Rat
Clone KAT1)
Format Purified
Antigen CD54 (ICAM-1)

The eBioKAT-1 monoclonal antibody reacts with mouse CD54 (ICAM-1), which is a 95kDa member of the immunoglobulin superfamily. CD54 is expressed at low levels on leukocytes and high endothelial venules, and expression increases in response to inflammatory cytokines. ICAM-1 binds to LFA-1 and this interaction is required for the transendothelial migration of T cells. ICAM-1-deficient mice are viable, however the migration of leukocytes to sites of inflammation is reduced leading to impaired immune and inflammatory responses. Based on the regulated expression of ICAM-1, it has been suggested that ICAM-1 may increase leukocyte extravasation at sites of inflammation, whereas the constitutively high expression of ICAM-2 mediates leukocyte traffic into non-inflamed tissue. The eBioKAT-1 monoclonal antibody recognizes a different epitope than the YN1/1.7.4 monoclonal antibody.