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CD49f Monoclonal Antibody (NKI-GoH3), Invitrogen™

Rat Monoclonal Antibody

Brand:  Invitrogen MA516884

Code : NEW

Additional Details : Weight : 0.01000kg

Product Code. 15276109

  • £215.00 / 100µg
Estimated Shipment: 23-05-2024
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Description

Description

For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. A suggested positive control for immunohistochemical applications is human tonsil.

CDf (Integrin alpha-6, ITGA6) is the integrin alpha chain alpha 6 protein. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signaling. Two transcript variants encoding different isoforms have been found for CDf. Functionally, integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals that affect cellular shape, mobility, and progression through the cell cycle in response to the extracellular matrix. Integrin receptors are composed of alpha and beta subunits, and form structural and functional linkages between the ECM (extra-cellular matrix) and intracellular cytoskeletal linker proteins. Signaling mediated by Intergrin/ECM interactions are also integrated with cellular responses to growth factor signaling to regulate cellular proliferation, cytoskeletal reorganization and other responses necessary for cellular survival. CDf is predominantly expressed by epithelia, and plays a critical structural role in the hemidesmosome. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells.
Specifications

Specifications

CD49f
Monoclonal
1 mg/mL
PBS with <0.1% sodium azide
P23229, Q61739
Itga6
BALB/c mouse mammary tumour cells
100 μg
Primary
Canine, Cynomolgus Monkey, Human, Mouse, Ovine, Porcine
Antibody
IgG2a
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation
NKI-GoH3
Unconjugated
Itga6
5033401O05Rik; AI115430; Alpha6p; CD49 antigen-like family member F; CD49f; DKFZp686J01244; FLJ18737; integrin alpha 6; integrin alpha-6; Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; integrin alpha6B; integrin subunit alpha 6; integrin, alpha 6; Itga6; ITGA6B; LOW QUALITY PROTEIN: integrin alpha-6; Processed integrin alpha-6; VLA-6
Rat
Protein G
RUO
100158200, 100856563, 101113656, 101925271, 16403, 3655
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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