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CD49b (Integrin α2) Rat, anti-Mouse, Biotin, Clone: DX5, STEMCELL Technologies
Rat Monoclonal Antibody
Brand: Stemcell Technologies 60020BT.1
This item is not returnable.
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Description
- The DX5 antibody reacts with murine CD49b (integrin α2), an ∼150 kDa type 1 transmembrane glycoprotein that associates non-covalently with CD29 (integrin β1) to form the heterodimeric CD49b/CD29 complex known as VLA-2, a receptor for extracellular matrix proteins such as collagen, E-cadherin, fibronectin, and laminin
- CD49b is highly expressed by platelets and is found on a majority of NK cells, on NKT cells, and on a small subset of CD8+ T cells; the latter population increases substantially following viral infection
- CD49b is also expressed by several tissues, including intestine, kidney, mammary gland, and lung
- Binding of the DX5 antibody has not been observed to affect the function of the VLA-2 integrin
- DX5 binding is, however, blocked by the clone HMα2 antibody
- This antibody clone has been verified for purity assessments of cells isolated with EasySep™ Mouse NK Cell Enrichment Kit (Catalog #19755)
Specifications
| CD49b (Integrin α2) | |
| Monoclonal | |
| Biotin | |
| 50 μg | |
| Mouse | |
| NK Cells |
| Immunohistochemistry, Flow Cytometry | |
| DX5 | |
| Rat | |
| Primary | |
| IgM κ |
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