Invitrogen™ CD46 Monoclonal Antibody (MEM-258)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA182140

Product Code. 11530113

Description

This product contains sodium azide; removal by dialysis is recommended prior to use in functional assays. For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Mouse anti Human CD46 antibody, clone MEM-258 recognizes the human CD46 cell surface antigen, a broadly expressed glycoprotein also known as membrane co-factor protein (MCP).

CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.

Specifications

• Antigen: CD46
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: P15529
• Gene Symbols: CD46
• Immunogen: HPB-ALL cell line.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Functional Assay, Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: MEM-258
• Conjugate: Unconjugated
• Gene: CD46
• Gene Alias: AHUS2; antigen identified by monoclonal antibody TRA-2-10; brain microvascular membrane cofactor; brain microvascular membrane cofactor protein CD46; Cd46; CD46 antigen, complement regulatory protein; CD46 complement regulatory protein; CD46 molecule; CD46 molecule, complement regulatory protein; CD46 splice variant; complement membrane cofactor protein; complement regulatory protein; Mcp; MCP; complement activation regulator; measles virus receptor; membrane cofactor protein; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); membrane cofactor protein variant 10; membrane cofactor protein variant 7; membrane cofactor protein variant 8; membrane cofactor protein variant 9; MGC26544; MIC10; soluble membrane cofactor protein variant 11; soluble membrane cofactor protein variant 12; soluble membrane cofactor protein variant 13; TLX; TRA2.10; trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 4179
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid