CD45RB Mouse anti-Human, PE, Clone: MEM-55, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen A15767

Product Code. 15215854

Description

CD45RB is a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, but share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RB is expressed in microglia and inflammatory cells. In addition to involvement in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is involved in DNA fragmentation during apoptosis. CD45 is expressed on cells of the human hematopoietic lineage with the exception of mature red cells.

Specifications

• Antigen: CD45RB
• Classification: Monoclonal
• Conjugate: PE
• Gene: PTPRC
• Gene Alias: B220, CD45, CD45R, GP180, LCA, LY5, T200
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 5788
• Content And Storage: 4° C
• Form: Liquid

• Applications: Flow Cytometry
• Clone: MEM-55
• Formulation: PBS with 0.2% BSA and 15mM sodium azide
• Gene Accession No.: P08575
• Gene Symbols: PTPRC
• Immunogen: Human CD45RB
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1