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CD45, TRI-COLOR, clone: HI30, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MHCD4506

Code : 50

Additional Details : Weight : 0.50000kg

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Product Code. 10058202

  • £214.00 / Each

Estimated Shipment
05-03-2021

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For Research Use Only. All usage must comply with product instructions.
 

Description

Description

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.

The TRI-COLOR™ conjugate is a tandem R-phycoerythrin (PE)-Cy5™ conjugate that permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source-the 488 nm line of the argon-ion laser.
Specifications

Specifications

CD45
Monoclonal
TRI-COLOR
PTPRC
Liquid
PTPRC
CD45 antigen
Purified
ASR, ASR/IVD
Antibody
Monoclonal
Human
Flow Cytometry
HI30
PBS with BSA, sucrose and 0.1% sodium azide
P08575
B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, CD45 antigen, T200 glycoprotein, T200 leukocyte common antigen, protein tyrosine phosphatase, receptor type, c polypeptide, receptor-type tyrosine-protein phosphatase C
Mouse
IgG1
0.5mL
Store at 2 - 8 °C.
Primary
5788
Videos
SDS
Documents