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CD45.1 Mouse anti-Mouse, APC, Clone: A20, BD
Mouse Monoclonal Antibody
£71.75 - £254.23
Specifications
| Antigen | CD45.1 |
|---|---|
| Clone | A20 |
| Concentration | 0.2mg/mL |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15881419
|
BD Biosciences
561873 |
25 μg |
 £74.90 £71.75 / Each Save £3.15 4% Off |
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|
15879588
|
BD Biosciences
558701 |
0.1 mg |
£265.00 £254.23 / Each Save £10.77 4% Off |
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Description
The A20 monoclonal antibody specifically binds to CD45 (Leukocyte Common Antigen) on all leukocytes of mouse strains expressing the CD45.1 alloantigen (eg, RIII, SJL/J, STS/A, DA). This alloantigen was originally named Ly-5.2, and this was the designation at the time that the antibody was characterized. The designation was later changed from Ly-5.2 to Ly-5.1 to conform with the convention that the .2 alloantigen designations be assigned to the C57BL/6 strain. mAb A20 has been reported not to react with leukocytes of most other mouse strains, which express the CD45.2 alloantigen. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C,respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction. The A20 antibody has been reported to inhibit some responses of B cells, from mice expressing the CD45.1 alloantigen, to antigens and LPS.
Specifications
| CD45.1 | |
| 0.2mg/mL | |
| Monoclonal | |
| Mouse | |
| Mouse | |
| SJL mouse thymocytes and splenocytes | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| A20 | |
| Flow Cytometry | |
| APC | |
| RUO | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| IgG2a κ | |
| Affinity Purified | |
| Ly-5; Lyt4; CD45R; LCA; Ptprc; Protein tyrosine phosphatase receptor type C |
For Research Use Only.
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