Invitrogen™ CD42d Monoclonal Antibody (1C2), APC, eBioscience™, Invitrogen™

Armenian Hamster Monoclonal Antibody

Product Code	Brand	Quantity
15330610	Invitrogen™ 17-0421-80	25 μg
15340610	Invitrogen™ 17-0421-82	100 μg

Description

Description: The monoclonal antibody 1C2 recognizes mouse and rat CD42d, a single transmembrane protein also known as platelet glycoprotein V (GPV). CD42d interacts with CD42a, CD42b and CD42c to form the receptor for von willebrand factor and thrombin. This functional complex plays a role in platelet adhesion. Expression of CD42d (unlike other markers such as CD41) is restricted to resting platelets and megakaryocytes and therefore is a good marker for development of megakaryocytes. Applications Reported: This 1C2 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 1C2 antibody has been tested by flow cytometric analysis of mouse platelets. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.

Natural killer (NK) cells in teleosts and their evolutionary homologue are a subpopulation of lymphocytes with properties that distinguish them from either B- or T-cells. NK cells are important effectors of innate immunity where they release cytokines, which in turn up-regulate other immunological functions. Monoclonal antibodies have been used to identify different surface antigens present on NK cells. These surface antigens have not only been used to identify NK cells, but also their functionally distinct subsets. The Cluster of Differentiation (CD) nomenclature was established to standardize the naming of NK cells.

Specifications

• Antigen: CD42d
• Concentration: 0.2 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Alias: CD42d; Glycoprotein 5; glycoprotein 5 (platelet); glycoprotein 5, platelet; glycoprotein V (platelet); glycoprotein V platelet; GP5; GPV; Platelet glycoprotein 5; platelet glycoprotein V; Platelete glycoprotein 5; Platelets GP V; PLGPV
• Gene Symbols: Gp5
• Primary or Secondary: Primary
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Gene: Gp5

• Clone: 1C2
• Applications: Flow Cytometry
• Conjugate: APC
• Host Species: Armenian Hamster
• Target Species: Mouse, Rat
• Gene Accession No.: O08742, O08770
• Gene ID (Entrez): 14729, 25259
• Isotype: IgG
• Purification Method: Affinity chromatography
• Product Type: Antibody

For Research Use Only.