CD42b Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA590903

Product Code. 16578041

Description

Immunogen sequence: ICEVSKVASH LEVNCDKRNL TALPPDLPKD TTILHLSENL LYTFSLATLM PYTRLTQLNL DRCELTKLQV DGTLPVLGTL DLSHNQLQSL PLLGQTLPAL TVLDVSFNRL TSLPLGALRG LGELQELYLK GNELKTLPPG LLTPTPKLEK LSLANNNLTE LPAGLLNGLE NLDTLLLQEN SLYTIPKGFF GSHLLPFAFL HGNPWLCNCE ILYFRRWLQD NAENVYVWKQ GVDVKAMTSN V; Positive Samples: Jurkat, K-562; Cellular Location: Membrane, Single-pass type I membrane protein

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.

Specifications

• Antigen: CD42b
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GP1BA
• Gene Symbols: GP1BA
• Immunogen: Recombit fusion protein containing a sequence corresponding to amino acids 19-259 of human GP1BA
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot
• Concentration: 1.92 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P07359
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2811
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid