CD41 Rat anti-Mouse, APC-eFluor 780, Clone: eBioMWReg30 (MWReg30), eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 47-0411-82

100UG Anti-Mouse CD41 APC-eFluor 780

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15559546

Quantity Price
1 £ 186.31 / 100µg
Estimated Shipment date
from Supplier 27-02-2017
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Description and Specification

Specification

Format Conjugated
Host Species Rat
Applications Flow Cytometry
Isotype IgG1
Quantity 100μg
Monoclonal or Polyclonal Monoclonal
Conjugate APC-eFluor 780
Antigen CD41
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Species Reactivity Mouse
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Primary or Secondary Primary
Gene Alias fibrinogen receptor, gpIIb/IIIa, integrin alpha Iib
Clone eBioMWReg30 (MWReg30)
Concentration 0.2mg/mL

The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb). While initially thought to be expressed exclusively on the surface of platelets and megakaryocytes, it has been demonstrated that CD41 is also expressed on hematopoietic progenitors in the embryo, fetus and adult. CD41 associates with CD61 (gpIIIa, integrin beta III) to form a receptor which plays a major role in platelet function, including binding of several adhesion molecules such as fibrinogen, fibronectin and vitronectin.

Recently, the SLAM-family markers, CD48 and CD150 have been used to reliably identify hematopoietic stem cells (HSC). Specifically, it was found that CD150+CD48- bone marrow cells were highly efficient in their ability to confer long-term multi-lineage reconstitution in irradiated mice. Furthermore, the efficiency of reconstitution was enhanced when HSCs were further enriched through the exclusion of CD41+ cells. Thus, the use of CD150+CD48-CD41- as an expression profile efficiently identifies hematopoietic stem cells.