Invitrogen™ CD41 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA596386

Product Code. 16589221

Description

Immunogen sequence: ALSNVEGFER LICNQKKENE TRVVLCELGN PMKKNAQIGI AMLVSVGNLE EAGESVSFQL QIRSKNSQNP NSKIVLLDVP VRAEAQVELR GNSFPASLVV AAEEGEREQN SLDSWGPKVE HTYELHNNGP GTVNGLHLSI HLPGQSQPSD LLYILDIQPQ GGLQCFPQPP VNPLKVDWGL PIPSPSPIHP AHHKRDRRQI FLPEPEQPSR LQDPVLVSCD SAPCTVVQCD LQEMARGQRA MVTVLAFLWL PSLYQRPLDQ FVLQSHAWFN VSSLPYAVPP LSLPRGEAQV WTQLLRALEE R; Positive Samples: Mouse liver; Cellular Location: Membrane, Single-pass type I membrane protein.

CD41, also known as platelet glycoprotein IIb or ITGA2B, is a protein composed of two subunits: a 120 kDa alpha subunit and a 23 kDa beta subunit. It interacts with CD61 (gpIIIa, integrin beta III) in the presence of calcium to form a functional adhesive protein receptor. Initially thought to be expressed exclusively on platelets and megakaryocytes, CD41 is also found on hematopoietic progenitors in the embryo, fetus, and adult, indicating its role in early stages of hematopoietic differentiation. CD41 plays a crucial role in platelet function and blood coagulation by mediating platelet aggregation. Upon blood vessel damage, CD41 binds to various adhesion molecules, including von Willebrand factor, fibrinogen, fibronectin, and vitronectin, facilitating platelet adhesion and aggregation. This receptor is essential for platelet function, contributing to the binding of several adhesion molecules and playing a significant role in hemostasis. Diseases associated with CD41 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 bleeding disorder, highlighting its importance in normal platelet function and blood coagulation processes.

Specifications

• Antigen: CD41
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Itga2b
• Gene Alias: AI172977; alpha IIb; alphaIIb; alphaIIb protein; BDPLT16; BDPLT2; CD41; CD41B; form 1; form 2; GP IIb; GP2B; GPalpha IIb; GPIIb; GT; GTA; HPA3; integrin alpha 2b; integrin alpha 2b (Cd41b); integrin alpha-IIb; Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2; integrin subunit alpha 2b; integrin subunit alpha IIb; integrin, alpha 2B; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); ITGA2B; ITGAB; platelet fibrinogen receptor, alpha subunit; platelet glycoprotein IIb; platelet glycoprotein IIb of IIb/II Ia complex; platelet glycoprotein IIb of IIb/IIIa complex; platelet membrane glycoprotein IIb; platelet-specific antigen BAK; PPP1R93; protein phosphatase 1, regulatory subunit 93
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16399, 3674
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.28 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P08514, Q9QUM0
• Gene Symbols: Itga2b
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 693-993 of human CD41/CD41/ITGA2B (NP_0004102).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG