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Invitrogen™ CD41 Polyclonal Antibody
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Product Code. 16589221
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Quantity:
100 μL
Unit Size:
100µL
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16589221 100 μL 100µL
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Product Code. 16589221 Supplier Invitrogen™ Supplier No. PA596386

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ALSNVEGFER LICNQKKENE TRVVLCELGN PMKKNAQIGI AMLVSVGNLE EAGESVSFQL QIRSKNSQNP NSKIVLLDVP VRAEAQVELR GNSFPASLVV AAEEGEREQN SLDSWGPKVE HTYELHNNGP GTVNGLHLSI HLPGQSQPSD LLYILDIQPQ GGLQCFPQPP VNPLKVDWGL PIPSPSPIHP AHHKRDRRQI FLPEPEQPSR LQDPVLVSCD SAPCTVVQCD LQEMARGQRA MVTVLAFLWL PSLYQRPLDQ FVLQSHAWFN VSSLPYAVPP LSLPRGEAQV WTQLLRALEE R; Positive Samples: Mouse liver; Cellular Location: Membrane, Single-pass type I membrane protein.

CD41, also known as platelet glycoprotein IIb or ITGA2B, is a protein composed of two subunits: a 120 kDa alpha subunit and a 23 kDa beta subunit. It interacts with CD61 (gpIIIa, integrin beta III) in the presence of calcium to form a functional adhesive protein receptor. Initially thought to be expressed exclusively on platelets and megakaryocytes, CD41 is also found on hematopoietic progenitors in the embryo, fetus, and adult, indicating its role in early stages of hematopoietic differentiation. CD41 plays a crucial role in platelet function and blood coagulation by mediating platelet aggregation. Upon blood vessel damage, CD41 binds to various adhesion molecules, including von Willebrand factor, fibrinogen, fibronectin, and vitronectin, facilitating platelet adhesion and aggregation. This receptor is essential for platelet function, contributing to the binding of several adhesion molecules and playing a significant role in hemostasis. Diseases associated with CD41 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 bleeding disorder, highlighting its importance in normal platelet function and blood coagulation processes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD41
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.28 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Itga2b
Gene Accession No. P08514, Q9QUM0
Gene Alias AI172977; alpha IIb; alphaIIb; alphaIIb protein; BDPLT16; BDPLT2; CD41; CD41B; form 1; form 2; GP IIb; GP2B; GPalpha IIb; GPIIb; GT; GTA; HPA3; integrin alpha 2b; integrin alpha 2b (Cd41b); integrin alpha-IIb; Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain; Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb light chain, form 2; integrin subunit alpha 2b; integrin subunit alpha IIb; integrin, alpha 2B; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); ITGA2B; ITGAB; platelet fibrinogen receptor, alpha subunit; platelet glycoprotein IIb; platelet glycoprotein IIb of IIb/II Ia complex; platelet glycoprotein IIb of IIb/IIIa complex; platelet membrane glycoprotein IIb; platelet-specific antigen BAK; PPP1R93; protein phosphatase 1, regulatory subunit 93
Gene Symbols Itga2b
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 693-993 of human CD41/CD41/ITGA2B (NP_0004102).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16399, 3674
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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