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CD40/TNFRSF5 Antibody (5D12), PE, Novus Biologicals™

Product Code. 18360741 Shop All Bio Techne Products
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0.1 mL
Unit Size:
0.10mL
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18360741 0.1 mL 0.10mL
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Product Code. 18360741 Supplier Novus Biologicals Supplier No. NBP281104PE

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Description

Human Monoclonal Antibody

CD40/TNFRSF5 Monoclonal specifically detects CD40/TNFRSF5 in Human, Cynomolgus Monkey samples. It is validated for Flow Cytometry, Product Image.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD40/TNFRSF5
Applications Flow Cytometry
Classification Monoclonal
Clone 5D12
Conjugate PE
Dilution Flow Cytometry
Formulation PBS
Gene Alias B cell surface antigen CD40, B-cell surface antigen CD40, Bp50B cell-associated molecule, CD40 antigen, CD40 molecule, TNF receptor superfamily member 5, CD40 type II isoform, CD40L receptor, CDw40, MGC9013, nerve growth factor receptor-related B-lymphocyte activation molecule, p50, TNFRSF5CD40 antigen (TNF receptor superfamily member 5), tumor necrosis factor receptor superfamily member 5, tumor necrosis factor receptor superfamily, member 5
Gene Symbols CD40
Host Species Human
Immunogen Anti-CD40/TNFRSF5 mAb 5D12, was generated by immunizing mice with sf9 insect cells expressing recombinant human CD40/TNFRSF5 and selected for the ability to bind EBV-immortalized human B cells. The variable regions from mu5D12 were cloned and used to construct chimeric humanized IgG4 5D12.
Purification Method Protein A purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Adaptive Immunity, Apoptosis, Asthma, B Cell Development and Differentiation Markers, Cancer, Hematopoietic Stem Cell Markers, Immunology, Signal Transduction, Stem Cell Markers
Primary or Secondary Primary
Gene ID (Entrez) 958
Test Specificity ch5D12 binds specifically to recombinant and native human CD40/TNFRSF5 ectodomain and has been shown to also bind CD40/TNFRSF5 in cynomolgus and marmoset monkeys. The antibody requires residues within D1 and D1/B2 for binding (Hager et al, 2003) (D1 domain is crucial for CD40L binding). Binding characteristics are very similar between humanized ch5D12 and mu5D12. CD40/TNFRSF5 is a glycoprotein of the TNFR superfamily and is expressed on all mature B cells, dendritic cells, activated monocytes, some endothelial cells and some epithelium including the thymus. CD40/TNFRSF5 binds to CD40L, and this interaction is involved in B-cell activation and proliferation, antigen-presenting cell (APC) activation, initiation of antigen-specific T-cell responses, immunoglobulin production, activation of effector macrophages isotype switching, homotypic adhesion and rescue from apoptosis.
Target Species Human, Cynomolgus Monkey
Content And Storage Store at 4°C in the dark.
Form Purified
Isotype IgG4 κ
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