CD38 Mouse, anti-Human, FITC, Clone: AT-1, STEMCELL Technologies

Mouse Monoclonal Antibody

Brand:  Stemcell Technologies 60131FI

Product Code. 15722612

Description

• The AT-1 antibody reacts with CD38, an ∼45 kDa type II integral membrane glycoprotein that is part of the ADP-ribosyl cyclase family
• CD38 is widely expressed at variable levels on hematopoietic cells including early B and T cell lineages, activated B and T cells, NK cells, monocytes, and dendritic cells
• It is strongly expressed in plasma cells
• CD38 is also expressed in some non-hematopoietic tissues such as brain, kidney, muscle, and pancreas
• CD38 is an ectoenzyme that acts as both an ADP-ribosyl cyclase and ADP-ribose (ADPR) hydrolase for the synthesis and hydrolysis of cyclic ADPR (cADPR) and NAADP
• cADPR acts as a second messenger for intracellular calcium mobilization to facilitate glucose-induced insulin secretion
• It has been shown that the AT-1 antibody mutually competes for binding with OKT10 and SUN-4B7, and all three clones only bind the native (not reduced) form of CD38

Specifications

• Antigen: CD38
• Classification: Monoclonal
• Conjugate: FITC
• Quantity: 100 Tests
• Target Species: Cynomolgus, Human, Rhesus Monkey
• Cell Type: B Cells, Hematopoietic Stem and Progenitor Cells, Plasma

• Applications: Flow Cytometry
• Clone: AT-1
• Host Species: Mouse
• Primary or Secondary: Primary
• Isotype: IgG1 κ