CD369 (Clec7A, Dectin-1) Mouse anti-Human, Non-human primate, PE, Clone: 15E2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-9856-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15507256

Quantity Price
1 £ 170.59 / 100 tests
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Format Conjugated
Host Species Mouse
Quantity 100 tests
Primary or Secondary Primary
Isotype IgG2a
Antigen CD369 (Clec7A, Dectin-1)
Monoclonal or Polyclonal Monoclonal
Clone 1.50E+03
Gene Alias Beta-glucan receptor, ClecSF12
Conjugate PE
Species Reactivity Human, Non-human primate
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 5μL (0.25μg)/test
Applications Flow Cytometry

This 15E2 monoclonal antibody reacts with human and non-human primate CD369, which is also known as the Dectin-1 or beta-glucan receptor or CLEC7A. CD369 is expressed predominantly on monocytes, macrophages, and dendritic cells. Moreover, this receptor can also be detected on neutrophils and lymphocytes, as well as induced by cytokines such as IL-4 or LPS. In humans, CD369 exists as two isoforms that arise due to alternative splicing. CD369 binds beta-1,3-glucan and plays an important role in activating signal transduction involved in the innate immune response to fungal and mycobacterial infections. Studies have also shown the involvement of CD369 in dendritic cell activation.

The 15E2 monoclonal antibody has been reported to recognize both isoforms of CD369 and activate dendritic cells. It does not crossreact to mouse CD369.