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CD369 (Clec7a, Dectin-1), PE, clone: 15E2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-9856-42

Code : NEW

Additional Details : Weight : 0.23750kg

 View more versions of this product

Product Code. 15507256

  • £174.50 / 100 tests


Estimated Shipment date
from Supplier 27-06-2018
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Description

Description

Description: This 15E2 monoclonal antibody reacts with human and non-human primate CD369, which is also known as the Dectin-1 or beta-glucan receptor or CLEC7A. CD369 is expressed predominantly on monocytes, macrophages, and dendritic cells. Moreover, this receptor can also be detected on neutrophils and lymphocytes, as well as induced by cytokines such as IL-4 or LPS. In humans, CD369 exists as two isoforms that arise due to alternative splicing. CD369 binds beta-1,3-glucan and plays an important role in activating signal transduction involved in the innate immune response to fungal and mycobacterial infections. Studies have also shown the involvement of CD369 in dendritic cell activation.The 15E2 monoclonal antibody has been reported to recognize both isoforms of CD369 and activate dendritic cells. It does not crossreact to mouse CD369.Applications Reported: This 15E2 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 15E2 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5μL (0.25μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

CD369 (Clec7A, Dectin-1)
Monoclonal
5μl/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
Q9BXN2
UNQ539/PRO1082, BGR, CANDF4, CLECSF12, DECTIN1,C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12, C-type lectin domain family 7 member A, C-type lectin superfamily member 12, DC-associated C-type lectin 1, beta-glucan receptor, dectin-1, dendritic cell-associated C-type lectin 1, dendritic cell-associated C-type lectin-1, lectin-like receptor 1
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
Non-human Primate
Flow Cytometry
1.50E+03
PE
CLEC7A
Conjugated
CLEC7A
IgG2a, kappa
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary
64581
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