missing translation for 'onlineSavingsMsg'
Learn More

CD366 (TIM3) Mouse anti-Human, eFluor® 450, Clone: F38-2E2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 48-3109-42

Code : NEW

Additional Details : Weight : 0.23750kg

Product Code. 15589736

This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.


Description

Description

Filtration: 0.2 μm post-manufacturing filtered. TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
Specifications

Specifications

CD366 (TIM3)
Monoclonal
5 μL/Test
PBS with 0.1% BSA, 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q8TDQ0
HAVCR2,TIM-3
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
F38-2E2
eFluor™ 450
HAVCR2
Liquid
HAVCR2
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
84868
Videos
Documents

For Research Use Only.