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CD366 (TIM3) Mouse anti-Human, eFluor® 450, Clone: F38-2E2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 48-3109-42

Code : NEW

Additional Details : Weight : 0.23750kg

Product Code. 15589736

This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Product Support team on 01509 555888 for assistance


Description

Description

Filtration: 0.2 μm post-manufacturing filtered. TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
Specifications

Specifications

CD366 (TIM3)
Monoclonal
5 μL/Test
PBS with 0.1% BSA, 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q8TDQ0
HAVCR2,TIM-3
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
F38-2E2
eFluor™ 450
HAVCR2
Liquid
HAVCR2
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
84868
Videos
Documents

For Research Use Only.