CD357 (AITR/GITR) Mouse anti-Human, PE, Clone: eBioAITR, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-5875-41

UNSPSC: 12000000

Code: NEW

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 12767300

Quantity Price
1 £ 67.24 / Each
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Concentration 5μL (0.5μg)/test
Quantity 25 tests
Applications Flow Cytometry
Clone eBioAITR
Host Species Mouse
Antigen CD357 (AITR/GITR)
Isotype IgG1
Regulatory Status RUO
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate PE
Gene Alias TNFRSF18, activation-inducible TNFR family member
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Format Conjugated
Species Reactivity Human

The monoclonal antibody reacts with human AITR, Activation Inducible TNFR family member, an approximately 25kDa member of the TNFR superfamily. AITR mRNA is detected in lymph node, peripheral blood leukocytes and weakly in spleen. AITR mRNA expression was upregulated within 24 hour on PMA/ionomycin or PHA stimulated PBMC. At the protein level, AITR is expressed by a small population of activated PBMC. AITR associates with TRAF1, TRAF2 and TRAF3 and induces nuclear factor NF-κB activation via TRAF2. Recently TL6 (AITRL) has been reported as the ligand for AITR. Interaction of AITR with AITRL is important for cross-talk between T lymphocytes and endothelial cells.