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CD35 Mouse anti-Human, Non-human primate, FITC, Clone: E11, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-0359-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15546386

  • £54.42 / 25 tests


Estimated Shipment date
from Supplier 28-06-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

This E11 monoclonal antibody reacts with human and non-human primate CD35, which is also known as complement receptor 1 (CR1). CD35 is expressed on B cells, T cell subsets, follicular dendritic cells, macrophages, neutrophils, eosinophils, and erythrocytes. This cell surface protein is also present on non-immune cells such as glomerular podocytes and Langerhans cells. CD35 binds the complement components C3b and C4b, which are derived from cleavage of C3 and C4, respectively, in the classical and alternative complement pathways. In humans, CD35 has been implicated in a variety of roles, including complement activation, transporting C3 complexes on erythrocytes, phagocytosis of complement-bound neutrophils and macrophages, B cell proliferation, and opsonization. Reports also indicate that Plasmodium falciparum, the pathogen that causes malaria, invades host erythrocytes by binding CD35. Decreased expression of CD35 on erythrocytes has been associated with systemic lupus erythematosus (SLE), type I diabetes, and rheumatoid arthritis.

The E11 antibody has been reported to crossreact to capuchin monkey, chimpanzee, cynomologus monkey, olive baboon, and rhesus macaque.
Description & Specifications

Specifications

CD35
E11
FITC
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.06μg)/test
Conjugated
Complement receptor 1, CR1, C3b/C4b receptor
IgG1
RUO
Primary
Non-human Primate