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CD34 Rabbit anti-Human, Polyclonal, Proteintech

Product Code. p-7205575 Shop All Proteintech Products
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Quantity:
150 μL
20 μL
Unit Size:
150µL
20µL
Product Code. Quantity unitSize
16853144 20 μL 20µL
16843144 150 μL 150µL
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Product Code. 16853144

Brand: Proteintech 144861AP20UL

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This item is not returnable. View return policy

Description

Rabbit Polyclonal Antibody

This antibody 14486-1-AP is raised against 33-286 amino acids of full protein.

CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.

Specifications

Antigen CD34
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CD34
Gene Accession No. P28906
Gene Alias CD34, CD34 molecule
Gene Symbols CD34
Host Species Rabbit
Immunogen CD34 Fusion Protein Ag5887
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 947
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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