CD335 (NKp46) Monoclonal Antibody (29A1.4), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Product Code	Brand	Quantity
17121222	Affymetrix eBioscience 16-3351-38	5 mg
17101222	Affymetrix eBioscience 16-3351-025	25 mg
17111222	Affymetrix eBioscience 16-3351-050	50 mg

Description

The MAb 29A1.4 recognizes mouse NKp46, also known as CD335. CD335, a member of the natural cytotoxicity receptor (NCR) family, is a glycoprotein with 2 Ig-like domains and a short cytoplasmic tail. Expression of CD335 is uniquely found on NK cells (including immature NK cells, defined as DX5- CD3-, and thereby allowing discrimination between NKT cells and NK cells (NKp46+, CD3-). Furthermore, unlike many of the NK markers which also stain NKT cells, staining with 29A1.4 is not strain specific. Staining has been shown on C57Bl/6, SJL, CBA/CA and BALB/C strains. NKp46 has been shown to play a role in NK cell-mediated lysis of several tumor cells and pathogen-infected cell lines. The 29A1.4 MAb has been shown to activate NK cells in vitro. The 29A1.4 MAb does not deplete NK cells in vivo.

CD335 (NKp46) Monoclonal antibody specifically detects CD335 (NKp46) in Mouse samples. It is validated for Flow Cytometry, Functional Assay

Specifications

• Antigen: CD335 (NKp46)
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with no preservative; pH 7.2
• Gene Alias: 1-Mar; Activating receptor 1; Ar1; CD335; hNKp46; Kilr1; KILR-1; Ly94; Ly-94; Lymphocyte antigen 94; Lymphocyte antigen 94 homolog; lymphocyte antigen 94 homolog (activating NK-receptor; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); mAR-1; MAR1 (mouse activating receptor 1); mNKp46; natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; natural killer cell receptor; NCR1; NK cell-activating receptor; NK receptor KILR-1; NKACTR; NKp46; NK-p46; NK-p46); rAR-1; rat-activating receptor 1
• Isotype: IgG2a κ
• Purification Method: Affinity chromatography
• Product Type: Antibody

• Clone: 29A1.4
• Applications: Flow Cytometry, Functional Assay
• Conjugate: Functional Grade
• Host Species: Rat
• Target Species: Mouse
• Gene Accession No.: Q8C567
• Gene ID (Entrez): 17086
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: NCR1