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CD33 Rat anti-Mouse, PE, Clone: 9A11-CD33, eBioscience™

Rat Monoclonal Antibody

£78.00 - £190.00

Specifications

Antigen CD33
Clone 9A11-CD33
Target Species Mouse
Conjugate PE
Isotype IgG1, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15566756
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Affymetrix eBioscience
12-0331-80
25 μg £78.00
25µg View alternative products
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Estimated Shipment
24-11-2020
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15576756
View Documents
Affymetrix eBioscience
12-0331-82
100 μg £190.00
100µg View alternative products
Save Up to 
»
Estimated Shipment
24-11-2020
Please to purchase this item. Need a web account? Register with us today!
Description

Description

CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, and these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. Further, CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. CD33 is also expressed on, and is a useful marker for, peripheral monocytes. CD33 is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias. Diseases associated with CD43 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
Specifications

Specifications

CD33
Mouse
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
9A11-CD33
PE
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.