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CD33 Mouse anti-Human, PerCP-Cyanine5.5, Clone: WM-53 (WM53), eBioscience™

Mouse Monoclonal Antibody

£115.00 - £219.00

Specifications

Antigen CD33
Clone WM-53 (WM53)
Target Species Human
Conjugate PerCP-Cyanine5.5
Isotype IgG1, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15569016
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Affymetrix eBioscience
45-0338-41
25 Tests £115.00
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Estimated Shipment
01-12-2020
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15579016
View Documents
Affymetrix eBioscience
45-0338-42
100 Tests £219.00
100 tests View alternative products
Save Up to 
»
Estimated Shipment
03-11-2020
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Description

Description

CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, and these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. Further, CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. CD33 is also expressed on, and is a useful marker for, peripheral monocytes. CD33 is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias. Diseases associated with CD43 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
Specifications

Specifications

CD33
Human
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
WM-53 (WM53)
PerCP-Cyanine5.5
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.