CD326 (EpCAM) Rat anti-Mouse, Biotin, Clone: G8.8, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-5791-80

Product Code. 15219859

Disclaimers:

For Research Use Only.

Description

The G8.8 monoclonal antibody reacts with the 40kDa mouse EpCAM (epithelial cellular adhesion molecule), also known as EGP40 (epithelial glycoprotein 40), 17-1A antigen, TACSTD1 (tumor-associated calcium signal transducer 1), and CD326. The immunogen used to generate the G8.8 antibody was the TE-71 thymic epithelial cell line. CD326 is expressed on the majority of epithelial cells, and is considered a pan-carcinoma antigen. CD326 mediates calcium-independent, homophilic, cell-cell adhesion and may function as a growth factor receptor. The antigen is being used as a target for immunotherapy treatment of human carcinomas. CD326 binds LAIR-1 (CD305) and LAIR-2 (CD306) to inhibit cellular activation and inflammation. This epithelial glycoprotein is now recognized as having an important role in tumor biology.

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Specifications

• Antigen: CD326 (EpCAM)
• Clone: G8.8
• Conjugate: Biotin
• Formulation: aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Host Species: Rat
• Quantity: 25μg
• Storage Requirements: Store at 2-8°C. Do not freeze.
• Monoclonal or Polyclonal: Monoclonal

• Applications: Flow Cytometry
• Concentration: 0.5mg/mL
• Format: Conjugated
• Gene Alias: epithelial cell adhesion molecule
• Isotype: IgG2a
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Murine