CD326 (EpCAM) Rat anti-Mouse, APC-eFluor 780, Clone: G8.8, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 47-5791-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15579586

Quantity Price
1 £ 76.43 / 25µg
Estimated Shipment date
from Supplier 03-04-2017
Add to basket


Description and Specification

Specification

Clone G8.8
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Conjugate APC-eFluor 780
Applications Flow Cytometry
Isotype IgG2a
Regulatory Status RUO
Gene Alias epithelial cell adhesion molecule
Quantity 25μg
Primary or Secondary Primary
Species Reactivity Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Rat
Concentration 0.2mg/mL
Monoclonal or Polyclonal Monoclonal
Format Conjugated
Antigen CD326 (EpCAM)

The G8.8 monoclonal antibody reacts with the 40kDa protein mouse EpCAM (epithelial cellular adhesion molecule), also known as EGP40 (epithelial glycoprotein 40), 17-1A antigen, TACSTD1 (tumor-associated calcium signal transducer 1), and CD326. The immunogen used to generate the G8.8 antibody was the TE-71 thymic epithelial cell line. CD326 is expressed on the majority of epithelial cells, and is considered a pan-carcinoma antigen. CD326 mediates calcium-independent, homophilic, cell-cell adhesion and may function as a growth factor receptor. The antigen is being used as a target for immunotherapy treatment of human carcinomas. CD326 binds LAIR-1 (CD305) and LAIR-2 (CD306) to inhibit cellular activation and inflammation. This epithelial glycoprotein is now recognized as having an important role in tumor biology.