CD325 (N-cadherin) Mouse anti-Human, APC, Clone: 8C11, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-3259-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15508086

Quantity Price
1 £ 182.82 / 100 tests
EU Stock 2
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Description and Specification

Specification

Primary or Secondary Primary
Gene Alias neural cadherin
Conjugate APC
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Concentration 5μL (0.25μg)/test
Isotype IgG1
Host Species Mouse
Applications Flow Cytometry
Clone 8C11
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Antigen CD325 (N-cadherin)
Format Conjugated
Quantity 100 tests

The 8C11 monoclonal antibody reacts with human CD325, also known as N-Cadherin. CD325 is a 130kDa member of the Cadherin superfamily, and consists of five extracellular repeats, a transmembrane domain and a cytoplasmic domain. CD325 deficient mice die at day 10 of gestation and embryos display major heart defects and malformed neural tubes and somites. Consistent with this, CD325 has been implicated in several aspects of cardiac development including the precardiac mesoderm, establishment of left-right symmetry and cardiac looping morphogenesis. Furthermore, CD325 is normally involved in inducing cell cycle arrest and its expression is frequently dysregulated in cancer cells.