CD324 (E-cadherin) Rat, Biotin, Clone: DECMA-1, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-3249-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15219789

Quantity Price
1 £ 66.65 / 25µg
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Applications Flow Cytometry
Applications Immunohistochemistry (Frozen)
Applications Western Blot
Isotype IgG1
Host Species Rat
Storage Requirements Store at 2-8°C. Do not freeze.
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Quantity 25μg
Gene Alias epithelial cadherin
Antigen CD324 (E-cadherin)
Regulatory Status RUO
Format Conjugated
Concentration 0.5mg/mL
Clone DECMA-1
Species Reactivity Canine, Human, Mouse
Conjugate Biotin
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The monoclonal antibody DECMA-1 recognizes mouse, human and canine CD324 also known as E-cadherin (Epithelial cadherin) or uvomorulin. Like the other cadherin family members P and N cadherin, E-cadherin is a transmembrane glycoprotein involved in intercellular adhesion. These proteins share a common basic structure. The extracellular portions of the proteins are largely composed of repeating domains, each with two consensus Ca2+-binding motifs. The cytoplasmic domain interacts with a-, b-, and g-catenins and actinins. These catenins connect E-cadherin with the cytoskeleton.

Expression is found in most epidermal cells including melanocytes and kerotinocytes. E-cadherin is localized at the intercellular boundaries of epithelial cells in several tissues, and is thought to play a role in maintenance of tissue integrity. Loss of E-cadherin function has been implicated in the progression of a variety of cancers.

E-Cadherin protein is sensitive to trypsin treatment, so exposure to trypsin should be minimized or avoided.

The monoclonal antibody DECMA-1 has been shown to have functional activity by disrupting adhesion in human, mouse and dog cells.