CD317 (BST2/PDCA-1) Rat anti-Mouse, Clone: eBio927, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-3172-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15218607

Quantity Price
1 £ 213.39 / 500µg
Estimated Shipment date
from Supplier 02-05-2017
Add to basket


Description and Specification

Specification

Host Species Rat
Antigen CD317 (BST2/PDCA-1)
Isotype IgG2b
Quantity 500μg
Regulatory Status RUO
Conjugate Unlabeled
Applications Flow Cytometry
Applications Functional Assay
Primary or Secondary Primary
Formulation aqueous buffer, no sodium azide
Species Reactivity Mouse
Monoclonal or Polyclonal Monoclonal
Format Purified
Gene Alias plasmacytoid DC Ag-1
Storage Requirements Store at 2-8°C.
Clone eBio927
Concentration 1mg/mL

The eBio927 monoclonal antibody reacts with PDCA-1 (BST2, CD317), a specific marker of plasmacytoid dendritic cells (pDC), also known as type I IFN-producing cells (IPC) in the naïve mouse. Mouse IPCs are typically CD11c+, CD11b-, B220+, Ly-6C+, and CD62L+. PDCA-1 is predominantly expressed by IPCs in the naïve mouse which represents a very minor population (<0.5%) of splenocytes. It is upregulated on numerous cell types following stimulation which triggers an IFN response. PDCA-1 cycles between cell surface and intracellular compartments and may function to regulate trafficking of secreted cytokines. PDCA-1 (BST2) is the protein recognized by antibody 120G8.

The eBio927 monoclonal antibody has also been shown to have functional activity. The epitope recognized by eBio927 is distinct from eBio129c; thus, the antibodies can be used to costain, purify and identify pDCs.