CD314 (NKG2D) Mouse anti-Human, PE, Clone: 5C6, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 12-5879-42
Code : NEW
Additional Details : Weight : 0.23750kg
DescriptionThe 5C6 monoclonal antibody reacts with the human NKG2D, a 42kDa lectin-like molecule expressed by NK cells, γδ T cells, some CD4+ and CD8+ T cells. Human NKG2D forms complexes with DAP10, a membrane adaptor protein, and has the ability to costimulate multiple NK activation receptors. The counter-receptor for human NKG2D has been identified as MICA/MICB expressed on epithelial tumors from lung, breast, kidney, ovary, prostate and colon carcinoma. 5C6 and 1D11 block binding of soluble MICA to γδ TCR T cell clones and inhibit lysis by these cells. 5C6 and 1D11 induced NKG2D function of redirected lysis of FcReceptor bearing P815 cells.
|Store at 2-8°C. Do not freeze. Light-sensitive material.|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|