CD314 (NKG2D) Mouse anti-Human, PE, Clone: 5C6, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-5879-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15597036

Quantity Price
1 £ 152.25 / 100 tests
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Concentration 5μL (0.25μg)/test
Isotype IgG2a
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 100 tests
Gene Alias KLRK1
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Species Reactivity Human
Conjugate PE
Clone 5C6
Applications Flow Cytometry
Regulatory Status RUO
Primary or Secondary Primary
Format Conjugated
Monoclonal or Polyclonal Monoclonal
Antigen CD314 (NKG2D)
Host Species Mouse

The 5C6 monoclonal antibody reacts with the human NKG2D, a 42kDa lectin-like molecule expressed by NK cells, γδ T cells, some CD4+ and CD8+ T cells. Human NKG2D forms complexes with DAP10, a membrane adaptor protein, and has the ability to costimulate multiple NK activation receptors. The counter-receptor for human NKG2D has been identified as MICA/MICB expressed on epithelial tumors from lung, breast, kidney, ovary, prostate and colon carcinoma. 5C6 and 1D11 block binding of soluble MICA to γδ TCR T cell clones and inhibit lysis by these cells. 5C6 and 1D11 induced NKG2D function of redirected lysis of FcReceptor bearing P815 cells.