CD29 Rat anti-Mouse, Clone: KMI6, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-0292-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15206897

Quantity Price
1 £ 140.02 / 500µg
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Clone KMI6
Species Reactivity Mouse
Primary or Secondary Primary
Conjugate Unlabeled
Concentration 0.5mg/mL
Host Species Rat
Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Applications Western Blotting
Isotype IgG2a
Monoclonal or Polyclonal Monoclonal
Gene Alias Integrin Beta 1, ITGB1, Fibronectin Receptor Beta, VLA-Beta
Regulatory Status RUO
Storage Requirements Store at 2-8°C.
Antigen CD29
Quantity 500μg
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Format Purified

The KMI6 monoclonal antibody reacts with mouse CD29 (integrin β1), a 120-130kDa member of the β integrin family expressed by leukocytes, endothelial, smooth muscle and epithelial cells. CD29 binds non-covalently with the α integrins CD49a-f, to form the VLA-1 through VLA-6 complexes, respectively, and also with CD51. These αβ integrin heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. All of the integrins which include CD29 bind to extracellular matrix proteins including collagen, laminin, fibronectin and vitronectin, whereas some CD29-containing integrins also interact with cellular receptors including VCAM-1 and MadCAM-1. The KMI6 antibody has been shown to be an activating antibody for β1 integrins, enhancing lymphocyte binding to fibronectin.