CD289 (TLR9) Monoclonal Antibody (eB72-1665), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9099-95

Product Code. 17170712

Description

eB72-1665 is generated against a portion of human toll-like receptor 9 (aa 273-288), a molecule reported to be expressed predominantly intracellularly. TLR9 is a ∽115-120 kDa molecule, which mediates response to unmethylated CpG dinucleotides in bacterial DNA. CpG DNA induces a strong T-helper-1-like inflammatory response and the proliferation of TLR9-positive human B cells. When stimulated with CpG DNA, TLR9-deficient (TLR9-/-) mice lacked splenocyte proliferation, inflammatory cytokine production from macrophages, and dendritic cell maturation, as compared with normal mice. To date, at least twelve members of the Toll family have been identified. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Members of the TLR family are involved in recognition and response to different microbial components including lipoproteins, peptidoglycans, and nucleic acids and play important roles in innate immunity and inflammation.

CD289 (TLR9) Monoclonal antibody specifically detects CD289 (TLR9) in Human samples. It is validated for Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Specifications

• Antigen: CD289 (TLR9)
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Accession No.: Q9NR96
• Host Species: Rat
• Quantity: 10 mg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: eB72-1665
• Conjugate: Unconjugated
• Gene: Tlr9
• Gene Alias: CD289; Tlr9; toll like receptor 9; toll-like receptor 9; UNQ5798/PRO19605
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54106
• Content And Storage: 4° C
• Form: Liquid