CD283 (TLR3) Mouse anti-Human, PE, Clone: TLR3.7, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-9039-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15229349

Quantity Price
1 £ 109.45 / 25µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Antigen CD283 (TLR3)
Clone TLR3.7
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Regulatory Status RUO
Species Reactivity Human
Isotype IgG1
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Primary or Secondary Primary
Gene Alias TLR-3, toll-like receptor 3
Monoclonal or Polyclonal Monoclonal
Concentration 0.2mg/mL
Host Species Mouse
Format Conjugated
Applications Flow Cytometry (Intracellular Staining)
Conjugate PE
Quantity 25μg

The TLR3.7 monoclonal antibody reacts with human Toll-like receptor 3 (TLR3). To date, at least twelve members of the Toll-like receptor family have been identified. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. In the innate immune response, TLRs recognize molecular patterns associated with microbial pathogens and induce antimicrobial activity. TLR3 recognizes double-stranded (ds)RNA, induces the activation of NF-κB through MyD88-dependent and -independent pathways, and the production of type I interferons (IFNs). TLR3.7 suppressed poly(I):poly(C)-mediated IFN-β production by human fibroblasts naturally expressing TLR3 on their surface.