CD282 (TLR2) Mouse anti-Human, Biotin, Clone: TL2.1, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-9922-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15310120

Quantity Price
1 £ 158.36 / 100µg
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Format Conjugated
Clone TL2.1
Gene Alias toll-like receptor 2
Applications Flow Cytometry
Regulatory Status RUO
Quantity 100μg
Isotype IgG2a
Primary or Secondary Primary
Antigen CD282 (TLR2)
Host Species Mouse
Concentration 0.5mg/mL
Conjugate Biotin
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C. Do not freeze.

The TL2.1 monoclonal antibody reacts with human Toll-like receptor 2 (TLR2). To date, at least ten members of the Toll family have been identified in human. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR2 is expressed by peripheral blood monocytes and is responsible for distinguishing different pathogens. TL2.1, a blocking antibody, has been used to study the role of TLR-2 as a pattern recognition receptor in microbial lipoprotein/lipopeptide induced cytokine production from human peripheral blood mononuclear cells. TL2.1 has been reported to immunoprecipitate human TLR2 (∽90 kDa) from PBMC and HMEC.