CD282 (TLR2), APC, clone: TL2.1, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 17-9922-42
Code : NEW
Additional Details : Weight : 0.23750kg
DescriptionDescription: The TL2.1 monoclonal antibody reacts with human Toll-like receptor 2 (TLR2). To date, at least ten members of the Toll family have been identified in human. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR2 is expressed by peripheral blood monocytes and is responsible for distinguishing different pathogens. TL2.1, a blocking antibody, has been used to study the role of TLR-2 as a pattern recognition receptor in microbial lipoprotein/lipopeptide induced cytokine production from human peripheral blood mononuclear cells. TL2.1 has been reported to immunoprecipitate human TLR2 (∽90 kDa) from PBMC and HMEC.Applications Reported: The TL2.1 antibody has been reported for use in flow cytometric analysis. It has also been reported in blocking of TLR2-mediated cytokine production.Applications Tested: This TL2.1 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (2 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2μm post-manufacturing filtered.
|PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2|
|TIL4, Toll-like Receptor 2, toll/interleukin 1 receptor-like 4, toll/interleukin-1 receptor-like protein 4|
|Store at 2-8°C. Do not freeze. Light-sensitive material.|
For Research Use Only.