missing translation for 'onlineSavingsMsg'
Learn More

CD28 Mouse anti-Human, PE, Clone: CD28.2, eBioscience™

Mouse Monoclonal Antibody

£63.50 - £138.00

Specifications

Antigen CD28
Clone CD28.2
Target Species Human
Conjugate PE
Isotype IgG1, kappa
View More Specs

Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15556746 View Documents Affymetrix eBioscience
12-0289-41
25 Tests £63.50
25 tests View alternative products
Save Up to 
»
Estimated Shipment date
from Supplier 15-05-2020
Please to purchase this item. Need a web account? Register with us today!
15566746 View Documents Affymetrix eBioscience
12-0289-42
100 Tests £138.00
100 tests View alternative products
Save Up to 
»
EU Stock 2 Please to purchase this item. Need a web account? Register with us today!
Description

Description

CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary’s Disease.
Specifications

Specifications

CD28
Human
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
CD28.2
PE
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.