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CD279 (PD-1), Functional Grade, clone: RMP1-14, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-9982-38

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15577836

  • £1099.93 / 5mg


Estimated Shipment date
from Supplier 27-07-2018
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Description

Description

Description: This antibody reacts with mouse PD-1 (programmed death-1), a 55kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Similar to J43, another mAb to mouse PD-1 (Cat. No. 16-9985), RMP1-14 blocks the binding of both B7-H1-Ig and B7-DC-Ig to PD-1 transfectants.Applications Reported: The RMP1-14 antibody has been reported for use in flow cytometric analysis.Applications Tested: The RMP1-14 antibody has been tested by flow cytometric analysis of 3 day Con A activated splenocytes. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay.Storage and handling: Use in a sterile environment.Filtration: 0.2μm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.
Specifications

Specifications

CD279 (PD-1)
Monoclonal
1mg/mL
PBS with no preservative; pH 7.2
Q02242
PD1
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Murine
Flow CytometryĆ¾Functional Assay
RMP1-14
Functional Grade
Pdcd1
Purified
Pdcd1
IgG2a, kappa
5mg
Store at 2-8°C.
Primary
18566
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