CD279 (PD-1) Rat anti-Mouse, Clone: RMP1-14, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9982-38

5MG Anti-Mouse CD279 (PD-1) Functional Grade Purified

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15577836

Quantity Price
1 £ 1676.1 / 5mg
Estimated Shipment date
from Supplier 24-02-2017
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Description and Specification

Specification

Antigen CD279 (PD-1)
Format Purified
Formulation aqueous buffer, no sodium azide, functional Grade
Host Species Rat
Applications Flow Cytometry
Applications Functional Assay
Isotype IgG2a
Quantity 5mg
Regulatory Status RUO
Species Reactivity Mouse
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Clone RMP1-14
Concentration 1mg/mL
Conjugate Unlabeled

This antibody reacts with mouse PD-1 (programmed death-1), a 55kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Similar to J43, another mAb to mouse PD-1 (Cat. No. 16-9985), RMP1-14 blocks the binding of both B7-H1-Ig and B7-DC-Ig to PD-1 transfectants.