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CD279 (PD-1) Rat anti-Mouse, Clone: RMP1-14, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9982-81

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15258307

  • £66.65 / 50µg


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For Research Use Only.


Specifications

Description

This antibody reacts with mouse PD-1 (programmed death-1), a 55kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Similar to J43, another mAb to mouse PD-1 (cat. 16-9985), RMP1-14 blocks the binding of both B7-H1-Ig and B7-DC-Ig to PD-1 transfectants.
Description & Specifications

Specifications

CD279 (PD-1)
RMP1-14
Unlabeled
Purified
IgG2a
RUO
Primary
Murine
Functional Assay
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Rat
50μg
Store at 2-8°C.
Monoclonal