CD279 (PD-1) Rat anti-Mouse, Clone: RMP1-14, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9982-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15258307

Quantity Price
1 £ 66.65 / 50µg
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Conjugate Unlabeled
Applications Flow Cytometry
Applications Functional Assay
Primary or Secondary Primary
Host Species Rat
Isotype IgG2a
Regulatory Status RUO
Quantity 50μg
Concentration 0.5mg/mL
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Format Purified
Storage Requirements Store at 2-8°C.
Antigen CD279 (PD-1)
Clone RMP1-14
Species Reactivity Mouse
Monoclonal or Polyclonal Monoclonal

This antibody reacts with mouse PD-1 (programmed death-1), a 55kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Similar to J43, another mAb to mouse PD-1 (cat. 16-9985), RMP1-14 blocks the binding of both B7-H1-Ig and B7-DC-Ig to PD-1 transfectants.