CD278 (ICOS) Armenian Hamster anti-Mouse, Rat, APC, Clone: C398.4A, eBioscience™

Armenian Hamster Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-9949-82

Product Code. 15380850

Disclaimers:

For Research Use Only.

Description

The C398.4A monoclonal antibody reacts with ICOS (Inducible Costimulatory molecule), also known as H4/CRP-1/AILIM, and cross-reacts with mouse and rat ICOS. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. A dimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1, is thought to play a protective role in inflammatory autoimmune diseases and be involved in the development of Th2 cells. C398.4A is reported to display strong costimulation of proliferation of T cell clones, intermediate costimulation on activated T cells, and weak costimulation on fresh resting T cells. It is a good costimulator of IL-10 production especially from pre-activated cells that express high level of H4/ICOS. The epitope recognized by C398.4A is different from that bound by the ICOSL (i.e., C398.4A does not block binding of ICOSL).

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Specifications

• Antigen: CD278 (ICOS)
• Clone: C398.4A
• Conjugate: Allophycocyanin
• Formulation: aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Host Species: Armenian Hamster
• Quantity: 100μg
• Storage Requirements: Store at 2-8°C. Do not freeze. Light-sensitive material.
• Monoclonal or Polyclonal: Monoclonal

• Applications: Flow Cytometry
• Concentration: 0.2mg/mL
• Format: Conjugated
• Gene Alias: Inducible T-cell COStimulator
• Isotype: IgG
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Rat