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CD278 (ICOS) Armenian Hamster anti-Mouse, Rat, APC, Clone: C398.4A, eBioscience™

Armenian Hamster Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-9949-82

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15380850

  • £133.91 / 100µg


EU Stock 2
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For Research Use Only.


Description

Description

The C398.4A monoclonal antibody reacts with ICOS (Inducible Costimulatory molecule), also known as H4/CRP-1/AILIM, and cross-reacts with mouse and rat ICOS. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. A dimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1, is thought to play a protective role in inflammatory autoimmune diseases and be involved in the development of Th2 cells. C398.4A is reported to display strong costimulation of proliferation of T cell clones, intermediate costimulation on activated T cells, and weak costimulation on fresh resting T cells. It is a good costimulator of IL-10 production especially from pre-activated cells that express high level of H4/ICOS. The epitope recognized by C398.4A is different from that bound by the ICOSL (i.e., C398.4A does not block binding of ICOSL).
Specifications

Specifications

CD278 (ICOS)
C398.4A
Allophycocyanin
Conjugated
Armenian Hamster
100μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Inducible T-cell COStimulator
IgG
RUO
Primary
Rat
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