CD273 (B7-DC) Rat anti-Mouse, Clone: 122, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9972-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15268297

Quantity Price
1 £ 237.85 / 500µg
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Gene Alias PD-L2
Applications Flow Cytometry
Quantity 500μg
Primary or Secondary Primary
Conjugate Unlabeled
Isotype IgG2a
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen CD273 (B7-DC)
Species Reactivity Mouse
Host Species Rat
Clone 122
Concentration 0.5mg/mL
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Format Purified
Storage Requirements Store at 2-8°C.

The 122 monoclonal antibody reacts with mouse B7-DC, also known as PD-L2. B7-DC, a recently identified member of the B7 family, has a predicted molecular weight of approximately 25kDa and belongs to the Ig superfamily. The mouse B7-DC has a short cytoplasmic tail (4aa). B7-DC is primarily expressed by subpopulations of dendritic cells and monocytes/macrophages in the mouse. Although B7-DC has structural and sequence similarities to the B7 family, it does not bind CD28/CTLA-4, rather it is a ligand for PD-1. The interactions between PD-1 and B7-DC/PD-L2 have been reported to be involved in costimulation or suppression of T cell proliferation depending on state of cellular activation. 122 has been demonstrated to block binding of TY25 (Cat. No.14-5986), another mAb specific for mouse B7-DC.