Invitrogen™ CD267 (TACI) Monoclonal Antibody (ebio8F10-3), APC, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Product Code	Brand	Quantity
15380790	Invitrogen™ 17-5942-81	50 μg
15390790	Invitrogen™ 17-5942-82	100 μg

Description

Description: The monoclonal antibody eBio8F10.3 recognizes TACI (Transmembrane Activator and Calcium-modulator and CAML Interactor) also known as CD267. TACI is a type III membrane protein belonging to the TNF receptor superfamily. The ligand for TACI has been shown to be BAFF (BLyS) and APRIL. TACI is expressed on the surface of a subset of maturing splenic B cells of the transitional type termed T2. Genetic studies have shown a role for TACI in both stimulation and inhibition of B cell proliferation. This actual role for TACI in the mouse has still not been determined. Recently human TACI has been shown to have repressive activities which inhibit BAFF-R function. Applications Reported: This ebio8F10-3 antibody has been reported for use in flow cytometric analysis. Applications Tested: This ebio8F10-3 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.

Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified. TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-kappa-B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

Specifications

• Antigen: CD267 (TACI)
• Concentration: 0.2 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Alias: 1200009E08Rik; CD267; CVID; CVID2; IGAD2; NEWGENE_1595998; RYZN; TACI; TNF receptor superfamily member 13B; Tnfrsf13b; TNFRSF14B; transmembrane activator and calcium-modulating and cyclophilin ligand interactor; transmembrane activator and CAML interactor; tumor necrosis factor receptor 13B; tumor necrosis factor receptor superfamily member 13B; tumor necrosis factor receptor superfamily, member 13B
• Gene Symbols: TNFRSF13B
• Primary or Secondary: Primary
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Gene: TNFRSF13B

• Clone: ebio8F10-3
• Applications: Flow Cytometry
• Conjugate: APC
• Host Species: Rat
• Target Species: Mouse
• Gene Accession No.: Q9ET35
• Gene ID (Entrez): 57916
• Isotype: IgG2a κ
• Purification Method: Affinity chromatography
• Product Type: Antibody

For Research Use Only.