CD266 (TWEAK Receptor) Monoclonal Antibody (ITEM-1), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9019-95

Product Code. 17150702

Description

The ITEM-1 mAb reacts with human TWEAK Receptor/Fn14 (fibroblast growth factor-inducible 14 kDa protein). Fn14 is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. Fn14 plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. TWEAK-induced cell death via Fn14 includes both apoptosis and necrosis and can be blocked by an anti-TWEAK antibody, CARL-1. Fn14 is expressed on HUVEC and in some cancer tissues but not on freshly isolated PBMCs. Fn14 mRNA expression has been identified during liver regeneration.

CD266 (TWEAK Receptor) Monoclonal antibody specifically detects CD266 (TWEAK Receptor) in Human samples. It is validated for Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)

Specifications

• Antigen: CD266 (TWEAK Receptor)
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Accession No.: Q9NP84
• Host Species: Mouse
• Quantity: 10 mg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)
• Clone: ITEM-1
• Conjugate: Unconjugated
• Gene: TNFRSF12A
• Gene Alias: AI255180; C87282; CD266; FGF-inducible 14; Fgfrp2; fibroblast growth factor regulated protein 2; fibroblast growth factor-inducible immediate-early response protein 14; Fibroblast growth factor-regulated protein 2; FN14; HPIP; TNF receptor superfamily member 12A; Tnfrsf12a; Tumor necrosis factor receptor superfamily member 12A; tumor necrosis factor receptor superfamily, member 12A; TweakR; TWEAK-R; tweak-receptor; type I transmembrane protein Fn14
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51330
• Content And Storage: 4° C
• Form: Liquid