CD254 (RANK Ligand) Rat anti-Mouse, Clone: IK22/5, eBioscience™

Rat Monoclonal Antibody

Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-5952-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg

Disclaimers: For Research Use Only.

Product Code. 15217627

Quantity Price
1 £ 109.45 / 50µg
EU Stock 3
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Description and Specification


Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate Unlabeled
Isotype IgG2a
Format Purified
Applications Flow Cytometry
Applications Functional Assay
Primary or Secondary Primary
Host Species Rat
Storage Requirements Store at 2-8°C.
Clone IK22/5
Species Reactivity Mouse
Gene Alias OPGL, TNFSF11, ODF
Monoclonal or Polyclonal Monoclonal
Quantity 50μg
Concentration 0.5mg/mL
Regulatory Status RUO
Antigen CD254 (RANK Ligand)

The IK22/5 monoclonal antibody reacts with mouse CD254 also known as TRANCE (TNF-related activation-induced cytokine receptor) and RANKL (receptor activator of NF-kappa B ligand) and OPGL (Osteoprotegerin Ligand). TRANCE is a type II membrane protein with predicted molecular weight of 35 kDa. Its extracellular domain is most closely related to TRAIL, FasL and TNF. TRANCE mRNA is upregulated by TCR stimulation and is expressed abundantly by mouse T cells not B cells in mouse thymus and lymph nodes. TRANCE-deficient mouse lacks osteoclasts. In addition, TRANCE has been shown to be involved in the interactions between T-dendritic and T-B cells. It was also found to be critical in osteoclast differentiation. The TRANCE-RANK interaction regulates the expression of the anti-apoptotic molecule Bcl-xL.