CD254 (RANK Ligand) Mouse anti-Human, PE, Clone: MIH24, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-6619-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15249259

Quantity Price
1 £ 182.82 / 100µg
EU Stock 2
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Description and Specification

Specification

Host Species Murine
Isotype IgG2b
Applications Flow Cytometry
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Regulatory Status RUO
Format Conjugated
Clone MIH24
Primary or Secondary Primary
Conjugate PE
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL
Antigen CD254 (RANK Ligand)
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Quantity 100μg
Gene Alias TRANCE, OPGL, RANKL

The MIH24 monoclonal antibody reacts with human TRANCE (TNF-related activation-induced cytokine receptor) also known as RANKL (receptor activator of NF-κB ligand) and OPGL (Osteoprotegerin Ligand). TRANCE is a type II membrane protein with predicted molecular weight of 35 kDa. Its extracellular domain is most closely related to TRAIL, FasL and TNF. TRANCE mRNA is upregulated by TCR stimulation. TRANCE-deficient mouse lacks osteoclasts. In addition, TRANCE has been shown to be involved in the interactions between T-dendritic and T-B cells. It was also found to be critical in osteoclast differentiation. The TRANCE-RANK interaction regulates the expression of the anti-apoptotic molecule Bcl-xL.